Endocrine Abstracts

Background: Hypoparathyroidism, a rare endocrine disorder characterised by low serum calcium due to low or insufficient parathyroid hormone levels, most commonly occurs post-surgery although can also occur due to predisposing genetic conditions or idiopathically. Hypoparathyroidism requires long-term medical management to minimise complications and detrimental impacts on health-related quality of life. Few real-world studies, particularly in the UK, have quantified healthcare ...

Background: Patients with hypoparathyroidism experience significant physical and cognitive symptoms and reduced health-related quality of life (HRQoL). Conventional therapy for hypoparathyroidism does not fully alleviate diminished HRQoL. The Hypoparathyroidism Patient Experience Scales (HPES) were developed to assess disease-specific physical and cognitive symptoms as well as the impact of hypoparathyroidsm on HRQol. TransCon PTH, an investigational long-acting prodrug of par...

Background: Individuals with hypoparathyroidism often experience a range of symptoms associated with reduced health-related quality of life (HRQoL) and work productivity. Conventional therapy aims to alleviate hypocalcemia and acute symptoms but fails to restore normal parathyroid hormone (PTH) physiology or improve HRQoL. In the PaTHway trial, 79% of participants treated with TransCon PTH vs. 5% placebo (P<0.0001) met the primary efficacy endpoint (normal serum c...